3rd European Symposium

Physiopathology of Sigma-1 Receptors

Università degli Studi di Bari “Aldo Moro”, Bari, Italy
October 7-9, 2021

About

The symposium will gather scientists from from European an Near-neighbour countries working on sigma-1 receptors. Communications will cover the latest progress in all aspects of research, from chemistry, pharmacology, cellular biology to drug development. This meeting, biennal climax of the Esteve-sponsored European network, offers a unique opportunity to vivid exchanges on sigma-1 receptor pharmacology.

Program

Thursday, October 7, 2021
Friday, October 8, 2021
Saturday, October 9, 2021
13:45
Welcome words
14:00
Plenary 1: Andrew KRUSE

Crystal structures of the σ2 receptor template large-library docking for selective chemotypes active in vivo

14:45
Oral 1: Michal GEVA

Sigma-1 receptor activation by Pridopidine regulates TFEB-mediated autophagy via nucleoporin POM121 in NSC34 C9 ALS/FTD model

15:05
Oral 2: Benjamin DELPRAT

Sigma-1 receptor is critical for UPR response and mitochondrial activity in larval Zebrafish

15:25
Oral 3: Edijs VAVERS

Sigma-1 receptor-dependent expression of the R2 Subunit of GABA-B receptor in Habenula

15:45
Coffee break
16:15
Oral 4: Baiba SVALBE

The sexual behaviour and functionality of spermatozoal mitochondria in Sig1R knockout mice

16:35
Oral 5: Chaitanya PATEL

The sigma-1 receptor is a type II membrane protein retained in the endoplasmic reticulum

16:55
Oral 6: Jean-Charles LIEVENS

Importance of sigma-1 receptor in amyotrophic lateral sclerosis: Genetic analysis in Drosophila

17:15
Oral 7: Simon COULY

Sigma-1 receptor chaperone deletion impacts glycolytic machinery and oxidative phosphorylation in cellular and animal models

17:35
Oral 8: Ilya BEZPROZVANNY

Sigma-1 receptor – A role in neuronal signaling and neurodegeneration

18:00
Excursion in the Old City
09:15
Plenary 2: Peter BRUST

Molecular imaging of sigma receptors: From bench to bedside

10:00
Oral 9: Preeti BORDE

Evaluating sigma-1 receptor expression and ligand-induced cellular stress signalling in breast cancer

10:20
Oral 10: Carla BADIA-PUIGGALÍ

VDAC inhibition promotes motoneuron survival after brachial plexus injury

10:40
Coffee break
11:10
Oral 11: Liga ZVEJNIECE

Metabolomic profiling of sigma-1 receptor knock-out mice

11:30
Oral 12: Tamar BARBAKADZE

p-Cresol induced cytotoxicity and protection by sigma ligands

11:50
Oral 13: Elene ZHURAVLIOVA

Protective effect of sigma ligands in p-cresol induced depression-like behavior

12:10
Poster session
12:40
Lunch time
14:00
Plenary 3: Valentina SABINO
Evidence for sigma receptors as a potential target for alcohol use disorders
14:45
Oral 14: Mikhail VORONIN

The contribution of chaperone sigma1R in the neuroprotective effect of Afobazole

15:05
Oral 15: Gundega STELFA

Amelioration of neurobehavioral deficits after traumatic brain injury in sigma- 1 receptor knockout mice

15:25
Oral 16: Lucie CROUZIER

Activation of the sigma-1 receptor chaperone alleviates disorders of Wolfram syndrome by restoring ER-mitochondrion signaling

15:45
Coffee break
16:15
Oral 17: Michael R. HAYDEN

Pridopidine, a highly potent and selective sigma-1 receptor agonist for the treatment of Huntington disease and amyotrophic lateral sclerosis

16:35
Oral 18: Michal GEVA

Pridopidine exerts neuroprotective effects via activation of the sigma-1 receptor in a biphasic manner

16:55
Oral 19: Gerardo LEDERKREMER

Sigma-1 receptor localization, topology and modulation of ER stress in Huntington's disease

17:15
Oral 20: Veronica MOREA

Deciphering the neuroprotective role of sigma1 receptor, an important function to overcome the symptoms of neurodegenerative disorders

17:35
Oral 21: Carla BARBARACI

Preliminary study of Haloperidol metabolite II valproate ester MRJF22 enantiomers as potential multifunctional agents against uveal melanoma

20:00
Symposium dinner
09:15
Round table: All participants welcomed
12:00
End of the meeting

Venue

Polifunzionale studenti
(ex Palazzo delle Poste)

Piazza C. Battisti, 1, Bari, Italy

Organizers

Scientific Committee
Dr. Carmen ABATE
Dipartimento di Farmacia – Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, Bari, Italy
Dr. Tangui MAURICE
MMDN, Université de Montpellier, EPHE, INSERM, Montpellier, France
Local Organizers
Dr. Mauro NISO
Dr. Angela STEFANACHI
Dr. Maria Grazia PERRONE
Dr. Antonio LAGHEZZA
Dipartimento di Farmacia – Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, Bari, Italy

Sponsors

Sponsored by:
Under the patronage of:

Contacts

For more information about the symposium, please contact Dr. Angela Stefanachi:

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