About
The symposium will gather scientists from from European an Near-neighbour countries working on sigma-1 receptors. Communications will cover the latest progress in all aspects of research, from chemistry, pharmacology, cellular biology to drug development. This meeting, biennal climax of the Esteve-sponsored European network, offers a unique opportunity to vivid exchanges on sigma-1 receptor pharmacology.
Program
13:45
Welcome words
14:00
Plenary 1: Andrew KRUSE
Crystal structures of the σ2 receptor template large-library docking for selective chemotypes active in vivo
14:45
Oral 1: Michal GEVA
Sigma-1 receptor activation by Pridopidine regulates TFEB-mediated autophagy via nucleoporin POM121 in NSC34 C9 ALS/FTD model
15:05
Oral 2: Benjamin DELPRAT
Sigma-1 receptor is critical for UPR response and mitochondrial activity in larval Zebrafish
15:25
Oral 3: Edijs VAVERS
Sigma-1 receptor-dependent expression of the R2 Subunit of GABA-B receptor in Habenula
15:45
Coffee break
16:15
Oral 4: Baiba SVALBE
The sexual behaviour and functionality of spermatozoal mitochondria in Sig1R knockout mice
16:35
Oral 5: Chaitanya PATEL
The sigma-1 receptor is a type II membrane protein retained in the endoplasmic reticulum
16:55
Oral 6: Jean-Charles LIEVENS
Importance of sigma-1 receptor in amyotrophic lateral sclerosis: Genetic analysis in Drosophila
17:15
Oral 7: Simon COULY
Sigma-1 receptor chaperone deletion impacts glycolytic machinery and oxidative phosphorylation in cellular and animal models
17:35
Oral 8: Ilya BEZPROZVANNY
Sigma-1 receptor – A role in neuronal signaling and neurodegeneration
18:00
Excursion in the Old City
09:15
Plenary 2: Peter BRUST
Molecular imaging of sigma receptors: From bench to bedside
10:00
Oral 9: Preeti BORDE
Evaluating sigma-1 receptor expression and ligand-induced cellular stress signalling in breast cancer
10:20
Oral 10: Carla BADIA-PUIGGALÍ
VDAC inhibition promotes motoneuron survival after brachial plexus injury
10:40
Coffee break
11:10
Oral 11: Liga ZVEJNIECE
Metabolomic profiling of sigma-1 receptor knock-out mice
11:30
Oral 12: Tamar BARBAKADZE
p-Cresol induced cytotoxicity and protection by sigma ligands
11:50
Oral 13: Elene ZHURAVLIOVA
Protective effect of sigma ligands in p-cresol induced depression-like behavior
12:10
Poster session
12:40
Lunch time
14:00
Plenary 3: Valentina SABINO
14:45
Oral 14: Mikhail VORONIN
The contribution of chaperone sigma1R in the neuroprotective effect of Afobazole
15:05
Oral 15: Gundega STELFA
Amelioration of neurobehavioral deficits after traumatic brain injury in sigma- 1 receptor knockout mice
15:25
Oral 16: Lucie CROUZIER
Activation of the sigma-1 receptor chaperone alleviates disorders of Wolfram syndrome by restoring ER-mitochondrion signaling
15:45
Coffee break
16:15
Oral 17: Michael R. HAYDEN
Pridopidine, a highly potent and selective sigma-1 receptor agonist for the treatment of Huntington disease and amyotrophic lateral sclerosis
16:35
Oral 18: Michal GEVA
Pridopidine exerts neuroprotective effects via activation of the sigma-1 receptor in a biphasic manner
16:55
Oral 19: Gerardo LEDERKREMER
Sigma-1 receptor localization, topology and modulation of ER stress in Huntington's disease
17:15
Oral 20: Veronica MOREA
Deciphering the neuroprotective role of sigma1 receptor, an important function to overcome the symptoms of neurodegenerative disorders
17:35
Oral 21: Carla BARBARACI
Preliminary study of Haloperidol metabolite II valproate ester MRJF22 enantiomers as potential multifunctional agents against uveal melanoma
20:00
Symposium dinner
09:15
Round table: All participants welcomed
12:00
End of the meeting
Venue
Polifunzionale studenti
(ex Palazzo delle Poste)
Piazza C. Battisti, 1, Bari, Italy
Organizers
Scientific Committee
Dr. Carmen ABATE
Dr. Tangui MAURICE
Local Organizers
Dr. Mauro NISO
Dr. Angela STEFANACHI
Dr. Maria Grazia PERRONE
Dr. Antonio LAGHEZZA
Sponsors
Sponsored by:
Under the patronage of:
Contacts
For more information about the symposium, please contact Dr. Angela Stefanachi: