The symposium will gather scientists from from European an Near-neighbour countries working on sigma-1 receptors. Communications will cover the latest progress in all aspects of research, from chemistry, pharmacology, cellular biology to drug development. This meeting, biennal climax of the Esteve-sponsored European network, offers a unique opportunity to vivid exchanges on sigma-1 receptor pharmacology.
Crystal structures of the σ2 receptor template large-library docking for selective chemotypes active in vivo
Sigma-1 receptor activation by Pridopidine regulates TFEB-mediated autophagy via nucleoporin POM121 in NSC34 C9 ALS/FTD model
Sigma-1 receptor is critical for UPR response and mitochondrial activity in larval Zebrafish
Sigma-1 receptor-dependent expression of the R2 Subunit of GABA-B receptor in Habenula
The sexual behaviour and functionality of spermatozoal mitochondria in Sig1R knockout mice
The sigma-1 receptor is a type II membrane protein retained in the endoplasmic reticulum
Importance of sigma-1 receptor in amyotrophic lateral sclerosis: Genetic analysis in Drosophila
Sigma-1 receptor chaperone deletion impacts glycolytic machinery and oxidative phosphorylation in cellular and animal models
Sigma-1 receptor – A role in neuronal signaling and neurodegeneration
Molecular imaging of sigma receptors: From bench to bedside
Evaluating sigma-1 receptor expression and ligand-induced cellular stress signalling in breast cancer
VDAC inhibition promotes motoneuron survival after brachial plexus injury
Metabolomic profiling of sigma-1 receptor knock-out mice
p-Cresol induced cytotoxicity and protection by sigma ligands
Protective effect of sigma ligands in p-cresol induced depression-like behavior
The contribution of chaperone sigma1R in the neuroprotective effect of Afobazole
Amelioration of neurobehavioral deficits after traumatic brain injury in sigma- 1 receptor knockout mice
Activation of the sigma-1 receptor chaperone alleviates disorders of Wolfram syndrome by restoring ER-mitochondrion signaling
Pridopidine, a highly potent and selective sigma-1 receptor agonist for the treatment of Huntington disease and amyotrophic lateral sclerosis
Pridopidine exerts neuroprotective effects via activation of the sigma-1 receptor in a biphasic manner
Sigma-1 receptor localization, topology and modulation of ER stress in Huntington's disease
Deciphering the neuroprotective role of sigma1 receptor, an important function to overcome the symptoms of neurodegenerative disorders
Preliminary study of Haloperidol metabolite II valproate ester MRJF22 enantiomers as potential multifunctional agents against uveal melanoma
Piazza C. Battisti, 1, Bari, Italy
For more information about the symposium, please contact Dr. Angela Stefanachi: